Analytical Data
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基因名
LCE1E
- Application
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别名
LCE1E; LEP5Late cornified envelope protein 1E; Late envelope protein 5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T753
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表达区间
1-118aa
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氨基酸序列
MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCCSQPSGGSSCCGGGSGQHSGGCC
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LCE1E, a member of the Late Cornified Envelope (LCE) family, has garnered attention in dermatological and biochemical research due to its significant role in skin barrier function and differentiation. The LCE gene family is predominantly expressed in the epidermis and is implicated in the formation of the cornified envelope, a crucial component of the skin's protective outer layer. Disruptions in LCE gene expression have been linked to various skin disorders, including atopic dermatitis, psoriasis, and other inflammatory conditions, which highlights the potential of LCE1E as a biomarker for skin health. Recent studies have focused on the recombinant expression of LCE1E to elucidate its functional mechanisms and interactions within the skin barrier. By utilizing advanced molecular biology techniques, researchers aim to characterize the protein's structure, post-translational modifications, and its role in keratinocyte differentiation. Understanding the function of LCE1E may lead to novel therapeutic strategies for skin disorders, as enhancing its expression or mimicking its activity could improve skin barrier integrity and overall health. Furthermore, insights gained from LCE1E research could contribute to the development of more effective topical treatments or preventive measures for skin diseases associated with compromised barrier function. Thus, ongoing investigations into the recombinant LCE1E protein hold promise for advancing the field of dermatology and improving patient outcomes.
