Analytical Data
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Gene name
LENG4
- Application
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Alternative Names
MBOAT7. BB1. LENG4. OACT7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96N66
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Expression Region
1-472aa
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AA Sequence
MSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEGRLESALRGRLSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFCIHFLALAALGLGLALGGGSPSRRKAASQPTSLAPEKLREE
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Molecular Weight
79.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LENG4, or leukocyte receptor tyrosine kinase (LTK) family member 4, is a type I transmembrane protein that belongs to the immunoglobulin superfamily and is expressed predominantly in leukocytes. Research surrounding LENG4 has gained traction due to its potential role in immune response regulation, cell signaling, and interaction with various pathogen recognition receptors. Its structural characteristics hint at a function in immune cell communication and activation, particularly in the context of infections and inflammation. Recent studies have indicated that LENG4 may interact with other immune receptors, influencing processes such as dendritic cell maturation and T-cell activation. Understanding the biochemical pathways and mechanisms involving LENG4 could unveil novel insights into immune system modulation, potentially leading to therapeutic applications in autoimmune diseases, cancer immunotherapy, and infectious diseases. Through recombinant protein studies, researchers aim to elucidate the functional properties, ligand binding affinities, and downstream signaling cascades associated with LENG4, thereby highlighting its significance in immunological research and potential clinical implications.
