Analytical Data
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Gene name
SNRPA
- Application
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Alternative Names
SNRPA；U1 small nuclear ribonucleoProtein A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09012
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Expression Region
2-282aa
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AA Sequence
AVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
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Molecular Weight
38.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNRPA (Small Nuclear Ribonucleoprotein Associated Protein A) is a critical component of the spliceosome, which is responsible for the processing of pre-mRNA in eukaryotic cells. This protein plays a vital role in the assembly and function of small nuclear ribonucleoproteins (snRNPs), which are instrumental in splicing introns from pre-mRNA to produce mature mRNA. Research into SNRPA has gained significance due to its implications in gene expression regulation, cell differentiation, and the development of certain diseases, including cancer and neurodegenerative disorders. Abnormalities in SNRPA and the splicing process are often linked to pathological conditions, highlighting the importance of understanding its structure and function. Additionally, SNRPA has been identified as a potential therapeutic target, with the prospect of modulating splicing pathways to develop novel treatments. Recent studies utilizing advanced biochemical and biophysical techniques have begun to unravel the intricate interactions and regulatory mechanisms involving SNRPA, making it a focal point in the field of molecular biology and genetics. Through understanding SNRPA's role and dynamics, researchers aim to contribute to the broader knowledge of RNA biology and its impact on human health.
