Analytical Data
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基因名
HIST2H2BE
- Application
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别名
HIST2H2BE；H2BFQ；HIST2H2BE；Histone H2B type 2-E
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16778
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表达区间
2-126aa
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氨基酸序列
PEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK
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分子量
13.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST2H2BE is a histone variant that plays a crucial role in chromatin organization and gene regulation. As a component of the nucleosome, it contributes to the structural integrity of chromatin and modulates the accessibility of DNA to transcription factors, thereby influencing gene expression. The study of HIST2H2BE has garnered attention due to its involvement in various biological processes, including cell differentiation and the maintenance of genome stability. Abnormal expression or mutations in histone variants, including HIST2H2BE, have been linked to several diseases, including cancer. Recent research has focused on the functional implications of HIST2H2BE in epigenetic regulation, exploring how its expression can impact cellular behavior in normal and pathological contexts. Furthermore, the development of recombinant HIST2H2BE proteins has enabled scientists to investigate their biochemical properties and interactions with other chromatin-associated factors. This research is significant as it may reveal new insights into the mechanisms underlying gene regulation and the potential role of histone variants in disease processes, paving the way for novel therapeutic strategies targeting epigenetic modifications.
