Analytical Data
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Gene name
NRG4
- Application
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Alternative Names
NRG4;Pro-neuregulin-4. membrane-bound isoform
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWG1
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Expression Region
1-61aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NRG4 (Neuregulin 4) is a member of the Neuregulin family, which plays crucial roles in cell signaling, development, and maintenance of various tissues, particularly in the nervous system and the immune system. The study of NRG4 has gained prominence due to its potential implications in several physiological and pathological processes, including neuronal development, synaptic plasticity, and metabolic regulation. Research indicates that NRG4 may be involved in neuroprotection and may offer therapeutic avenues for neurodegenerative diseases. Additionally, there is growing interest in its role in the regulation of immune responses, which could have implications for autoimmune diseases and inflammation. In recent studies, the recombinant protein form of NRG4 has been explored for its functional properties, revealing insights into its receptor interactions and downstream signaling pathways. Understanding the molecular mechanisms of NRG4 through recombinant protein studies can facilitate the development of targeted therapies and innovative treatment strategies for conditions such as Alzheimer's disease, schizophrenia, and various metabolic disorders. Given its multifunctional nature, NRG4 presents a promising target for therapeutic intervention, emphasizing the need for further research into its biological roles and potential applications in regenerative medicine and treatment of chronic diseases. This growing body of literature underscores the importance of NRG4 in health and disease, paving the way for future investigations focused on its mechanisms of action and therapeutic potential.
