Analytical Data
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基因名
PSMD5
- Application
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别名
PSMD5;KIAA0072;26S proteasome non-ATPase regulatory subunit 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16401
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表达区间
1-504aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSEFMAAQALALLREVARLEAPLEELRAL HSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLLQAM EPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEILNNAE LLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVM KTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRA TCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVK FFGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSN VEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQ QTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTAIANQP WAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGN PNYLRLRTYLSEGPYYVKPVSTTAVEGAE
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分子量
59 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD5 is a pivotal component of the 26S proteasome, a multi-subunit protease complex responsible for protein degradation in eukaryotic cells. The proteasome plays a crucial role in regulating various cellular processes, including the cell cycle, signal transduction, and apoptosis, by ensuring the controlled degradation of misfolded, damaged, or unneeded proteins. PSMD5, specifically, functions as a non-ATPase regulatory subunit and is involved in the recognition and translocation of ubiquitinated substrates into the proteolytic core of the proteasome. Emerging research highlights the importance of PSMD5 in various diseases, particularly cancer, where its expression levels can influence tumor progression and therapeutic responses. Additionally, altered PSMD5 activity has been implicated in neurodegenerative disorders, underscoring its significance in maintaining cellular homeostasis. Recent studies also suggest potential therapeutic strategies targeting the PSMD5 pathway, aiming to enhance proteasomal activity or inhibit specific interactions critical for disease progression. Understanding the structural and functional aspects of PSMD5, along with its regulatory mechanisms, can pave the way for novel interventions in diseases associated with proteasome dysfunction. Thus, the study of PSMD5 not only provides insights into fundamental cellular processes but also opens avenues for developing targeted therapies in oncology and other diseases characterized by protein homeostasis disruptions.
