Analytical Data
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基因名
MSI1
- Application
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别名
Msi 1; Msi1; MSI1H_HUMAN; Musashi homolog 1; Musashi RNA binding protein 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43347
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表达区间
1-362 aa
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氨基酸序列
METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG YH
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分子量
39.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MSI1, or Musashi-1, is a highly conserved RNA-binding protein that plays a critical role in regulating cellular processes such as differentiation, proliferation, and stem cell maintenance. It is particularly significant in the context of neural development and cancer biology. Research has shown that MSI1 is involved in the post-transcriptional regulation of target mRNAs, influencing processes such as translation and stability, which can affect cell fate decisions. In various types of cancer, including glioblastoma and leukemia, MSI1 is often overexpressed, highlighting its potential as a biomarker for tumor progression and a target for therapeutic intervention. The study of recombinant MSI1 protein allows researchers to investigate its functional mechanisms in detail, including its interactions with RNA and other regulatory proteins. Understanding the structural and functional characteristics of MSI1 can provide insights into its role in normal physiology and disease states, paving the way for novel approaches in cancer treatment and regenerative medicine. By exploring the biochemical properties of MSI1, scientists aim to unravel its contributions to the maintenance of stem cell populations and the pathways leading to tumorigenesis, ultimately enhancing our therapeutic strategies.
