Analytical Data
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Gene name
RCAN3
- Application
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Alternative Names
RCAN3;DSCR1L2;Calcipressin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKA8
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Expression Region
56-241aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RCAN3, also known as Regulator of Calcineurin 3, is a member of the RCAN family of proteins, which are involved in regulating calcium signaling pathways through the inhibition of calcineurin, a calcium and calmodulin-dependent phosphatase. The significance of RCAN3 has garnered attention due to its role in various physiological processes including cardiac development, cellular proliferation, and apoptosis. Studies suggest that dysregulation of RCAN3 may contribute to pathologies such as heart disease and neurodegenerative disorders. Furthermore, RCAN3 has been implicated in the response to stress and inflammation, hinting at its potential role in autoimmune diseases. The interest in RCAN3 extends to its potential as a therapeutic target, as modulating its activity could influence disease outcomes. Researchers are increasingly focused on characterizing the molecular mechanisms underlying RCAN3 function, including its interactions with other cellular proteins and its regulation by signaling pathways. Understanding these mechanisms could provide insights into its pathways and functions, making it a promising avenue for therapeutic exploration in diseases where calcium signaling is disrupted. Additionally, investigations into the structural properties of RCAN3 may facilitate the development of pharmacological agents aimed at modulating its activity in various clinical contexts. Thus, ongoing research on RCAN3 is aimed not only at elucidating its biological roles but also at unraveling its therapeutic potential in a range of diseases associated with calcium dysregulation.
