Analytical Data
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基因名
FRS3
- Application
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别名
FRS3；Fibroblast growth factor receptor substrate 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43559
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表达区间
2-492aa
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氨基酸序列
GSCCSCLNR DSVPDNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH RREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL LQDLMQCNSI NVMEEPVIIT RNSHPAELDL PRAPQPPNAL GYTVSSFSNG CPGEGPRFSA PRRLSTSSLR HPSLGEESTH ALIAPDEQSH TYVNTPASED DHRRGRHCLQ PLPEGQAPFL PQARGPDQRD PQVFLQPGQV KFVLGPTPAR RHMVKCQGLC PSLHDPPHHN NNNEAPSECP AQPKCTYENV TGGLWRGAGW RLSPEEPGWN GLAHRRAALL HYENLPPLPP VWESQAQQLG GEAGDDGDSR DGLTPSSNGF PDGEEDETPL QKPTSTRAAI RSHGSFPVPL TRRRGSPRVF NFDFRRPGPE PPRQLNYIQV ELKGWGGDRP KGPQNPSSPQ APMPTTHPAR SSDSYAVIDL KKTVAMSNLQ RALPRDDGTA RKTRHNSTDL PL
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分子量
54.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FRS3 (Focal Adhesion Kinase Related Protein 3) is a relatively less-studied member of the focal adhesion kinase family, which plays a crucial role in cell adhesion, migration, and signaling. Its involvement in various cellular processes has garnered attention in recent years, particularly in the context of cancer biology, where abnormal expression and activity of focal adhesion proteins are often linked to tumor progression and metastasis. Research indicates that FRS3 may participate in the regulation of cell-matrix interactions and influence cytoskeletal dynamics, suggesting its potential role in modulating cellular responses to external stimuli. Furthermore, preliminary studies have shown that FRS3 might interact with multiple signaling pathways, including those governing cell survival and proliferation, thereby implicating it in crucial physiological and pathological processes. Investigating the structure and functionality of FRS3, along with its interactions in the cellular environment, could provide valuable insights into its role in health and disease. Understanding the mechanisms behind FRS3's activity could open new avenues for therapeutic strategies targeting diseases linked to aberrant cell adhesion and migration, particularly in metastatic cancers. Overall, the exploration of FRS3 as a research focus represents a promising frontier in cell biology and cancer research, aiming to elucidate the complexities of cellular behavior and potential interventions.
