Analytical Data
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基因名
ARHGEF9
- Application
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别名
EIEE8; HPEM 2; hPEM-2 collybistin; KIAA0424; mKIAA0424
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43307
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表达区间
1-516aa
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氨基酸序列
MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK
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分子量
56.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGEF9, a member of the guanine nucleotide exchange factor (GEF) family, plays a critical role in regulating the Rho GTPase signaling pathway, which is involved in various cellular processes including cytoskeletal organization, cell migration, and division. The gene encoding ARHGEF9 has been associated with several neurodevelopmental disorders, highlighting its importance in neuronal function and morphology. Recent studies have shown that ARHGEF9 can influence synaptic formation and plasticity, suggesting its potential involvement in learning and memory processes. Given its significant biological roles, researchers have been increasingly interested in obtaining recombinant ARHGEF9 proteins for in-depth functional studies. The recombinant proteins can be used to investigate ARHGEF9's molecular mechanisms, interaction with other cellular proteins, and its impact on Rho GTPase activity. Furthermore, understanding the structure and function of ARHGEF9 can provide insights into therapeutic strategies for diseases associated with its dysregulation. Consequently, the study of recombinant ARHGEF9 not only furthers our knowledge of fundamental biological processes but also paves the way for potential clinical applications in the treatment of neurodevelopmental disorders.
