Analytical Data
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基因名
PHLDA3
- Application
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别名
PHLA3_HUMAN; PHLDA 3; phlda3; Pleckstrin homology like domain family A member 2; Pleckstrin homology like domain family A member 3; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; TDAG51/Ipl homologue 1; TIH 1; TIH1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5J5
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表达区间
1-127 aa
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氨基酸序列
MTAAATATVL KEGVLEKRSG GLLQLWKRKR CVLTERGLQL FEAKGTGGRP KELSFARIKA VECVESTGRH IYFTLVTEGG GEIDFRCPLE DPGWNAQITL GLVKFKNQQA IQTVRARQSL GTGTLVS
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分子量
13.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHLDA3 (Pleckstrin Homology-Like Domain Family A Member 3) is a protein that has garnered attention in recent years due to its potential role in various physiological and pathological processes, including cancer. As a member of the pleckstrin homology domain-containing proteins, PHLDA3 is implicated in cellular signaling pathways, particularly those related to cell growth and apoptosis. It is known to exhibit tumor suppressor properties, and its expression is often regulated by growth factors, indicating a critical role in cellular responses to environmental stimuli. Research has shown that PHLDA3 can influence the survival of cells under stress conditions, and its dysregulation may contribute to tumorigenesis. Additionally, studies have reported its involvement in hematopoiesis and the modulation of immune responses. Given these diverse functions, the recombinant expression of PHLDA3 is imperative for elucidating its biological roles and mechanisms of action. Production of recombinant PHLDA3 facilitates detailed investigations into its structural properties, binding interactions, and functional assays, which can ultimately enhance our understanding of its therapeutic potential. Therefore, ongoing research focuses not only on the biochemical characterization of this protein but also on its potential as a biomarker for cancer diagnosis and prognostication, further establishing the significance of PHLDA3 in both basic science and clinical applications.
