Analytical Data
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基因名
BAZ2B
- Application
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别名
BAZ2B; BAZ2B_HUMAN; Bromodomain adjacent to zinc finger domain 2B
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UIF8
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表达区间
1-643aa
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氨基酸序列
MGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEESSSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTSGRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKLRQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKKAKKQQAIMLLRRSGSKKNR
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分子量
98.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAZ2B, or Bromodomain Adjacent to Zinc Finger Domain 2B, is a member of the Bromodomain and extraterminal (BET) family of proteins, playing a critical role in chromatin remodeling and gene expression regulation. It is involved in various cellular processes such as transcriptional activation, the DNA damage response, and cell cycle progression. The study of BAZ2B has gained traction due to its implications in several diseases, including cancer, where aberrant expression and function can contribute to tumorigenesis. Researchers have been focusing on the structure and function of BAZ2B to understand its interactions with acetylated lysines on histones and non-histone proteins, which are essential for its role in modulating chromatin dynamics. The exploration of BAZ2B as a potential therapeutic target has intensified, aiming to develop inhibitors that can disrupt its function in pathological conditions, particularly in cancers characterized by dysregulated gene expression. Through biochemical assays, structural biology, and cellular models, the investigation into BAZ2B is expected to unravel its mechanistic pathways and provide insights into novel strategies for targeted therapies.
