Analytical Data
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基因名
FcgR3A
- Application
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别名
FcgR3A；CD3Z；T-cell surface glycoProtein CD3 zeta chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08637
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表达区间
17-208aa
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氨基酸序列
GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESL ISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRW VFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKD SGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFFPPGYQHHHHHH
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fc gamma receptor IIIA (FcgR3A) is a critical component of the immune system, primarily involved in the recognition and clearance of antibody-coated pathogens through processes such as antibody-dependent cellular cytotoxicity (ADCC). It is predominantly expressed on natural killer (NK) cells, macrophages, and some other immune cells, where it plays a pivotal role in mediating immune responses and contributing to the efficacy of therapeutic antibodies in cancer and infectious diseases. The study of FcgR3A recombinant protein is vital for understanding its structural and functional dynamics, which can provide insights into its role in immunological processes. Recent research has focused on characterizing the binding affinity of FcgR3A to different antibodies, elucidating its signaling mechanisms, and exploring its interactions with various ligands. By employing recombinant technology, researchers can produce this receptor in larger quantities for functional assays, structural studies, and as a potential therapeutic target. Additionally, investigating FcgR3A polymorphisms has been instrumental in understanding variations in immune responses among individuals, which can influence the clinical outcomes of antibody therapies. Overall, the research on FcgR3A recombinant protein holds significant promise for enhancing our understanding of immune regulation and improving the design of novel immunotherapeutics.
