Analytical Data
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Gene name
TCN2
- Application
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Alternative Names
TCN2；TC2；Transcobalamin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20062-1
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Expression Region
1-427aa
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AA Sequence
MRHLGAFLFL LGVLGALTEM CEIPEMDSHL VEKLGQHLLP WMDRLSLEHL NPSIYVGLRL SSLQAGTKED LYLHSLKLGY QQCLLGSAFS EDDGDCQGKP SMGQLALYLL ALRANCEFVR GHKGDRLVSQ LKWFLEDEKR AIGHDHKGHP HTSYYQYGLG ILALCLHQKR VHDSVVDKLL YAVEPFHQGH HSVDTAAMAG LAFTCLKRSN FNPGRRQRIT MAIRTVREEI LKAQTPEGHF GNVYSTPLAL QFLMTSPMRG AELGTACLKA RVALLASLQD GAFQNALMIS QLLPVLNHKT YIDLIFPDCL APRVMLEPAA ETIPQTQEII SVTLQVLSLL PPYRQSISVL AGSTVEDVLK KAHELGGFTY ETQASLSGPY LTSVMGKAAG EREFWQLLRD PNTPLLQGIA DYRPKDGETI ELRLVSW
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCN2, or the transferrin cytosolic/nuclear protein, plays a significant role in iron metabolism and cellular processes. Its primary function is associated with iron transport and regulation, which is crucial for maintaining cellular homeostasis. Research has shown that TCN2 is not only involved in iron uptake but also interacts with various cellular pathways, influencing cell proliferation, differentiation, and apoptosis. Given its essential role in cellular iron distribution and potential implications in iron-related disorders, TCN2 has garnered attention in the fields of molecular biology and medicine. The recombinant production of TCN2 protein allows for detailed functional studies, enabling researchers to unravel its mechanisms of action and explore its therapeutic potential in conditions such as anemia, cancer, and neurodegenerative diseases. By utilizing advanced recombinant DNA technology, scientists are now able to produce high-purity TCN2 proteins to elucidate its structure-function relationship, interaction with other biomolecules, and its impact on iron metabolism. This research not only enhances our understanding of TCN2's biological significance but also opens avenues for developing targeted therapies aimed at modulating its activity in pathological states where iron homeostasis is disrupted. Furthermore, the ability to generate functional recombinant TCN2 contributes to the advancement of innovative diagnostic tools and potential interventions in iron-related disorders. Overall, the ongoing research on TCN2 recombinant protein represents a critical step toward uncovering the complexities of iron regulation in human health and disease.
