Analytical Data
-
基因名
METAP2
- Application
-
别名
METAP2；MNPEP；P67EIF2；Methionine aminopeptidase 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P50579
-
表达区间
1-478aa
-
氨基酸序列
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA AGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKK KKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRT TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKL EDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKI DFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGG EATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTK HLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI KGSYTAQFEHTILLRPTCKEVVSRGDDY
-
分子量
70 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
METAP2 (Methionine Aminopeptidase 2) is a crucial enzyme involved in the processing of nascent peptides by removing the N-terminal methionine, which plays a vital role in protein maturation and regulation. Research into METAP2 has garnered significant attention due to its implications in various biological processes and diseases. Notably, METAP2 is implicated in cancer progression, as it can affect the stability of oncogenic proteins and influence cellular signaling pathways. Loss of METAP2 function has been associated with increased cellular stress responses and altered apoptosis, contributing to tumorigenesis. Additionally, METAP2 has been identified as a potential target for therapeutic interventions, with small-molecule inhibitors being developed to modulate its activity in cancer therapy. Understanding the structure-function relationship of METAP2 and its role in protein metabolism can provide insights into its potential as a biomarker for disease and a target for drug development. Recent advances in recombinant protein technology have enabled the production of METAP2 for detailed biochemical studies, allowing researchers to investigate its enzymatic properties and interactions with various substrates. This knowledge is essential for the development of METAP2-targeted therapies and for elucidating its role in cancer and other pathologies, thereby advancing our understanding of cellular homeostasis and disease mechanisms.
