Analytical Data
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基因名
CCNF
- Application
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别名
Ccnf; CCNF_HUMAN; Cyclin-F; F box only Protein 1; F-box only Protein 1; FBX1; FBXO1; G2 mitotic specific cyclin F; G2/mitotic specific cyclin F
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41002
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表达区间
1-786aa
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氨基酸序列
MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMNLGLVRL
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分子量
114 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCNF, also known as Cyclin F, is a crucial protein that plays a significant role in cell cycle regulation and has garnered considerable attention in recent years due to its involvement in various cellular processes and diseases. As a member of the cyclin family, CCNF interacts with cyclin-dependent kinases (CDKs) to regulate the progression of cells through the cell cycle, particularly during the G2/M transition. Research has increasingly focused on the implications of CCNF dysregulation in cancer, where its altered expression can contribute to tumorigenesis and poor prognosis. Studies have demonstrated that CCNF is involved in regulating DNA repair mechanisms and maintaining genomic stability, highlighting its importance in preventing malignancies. Furthermore, recent findings have established that CCNF can modulate the stability and activity of several key oncogenic and tumor suppressor proteins, linking it to critical pathways in cancer biology. The exploration of CCNF as a potential therapeutic target is therefore profound, aiming to develop innovative strategies for cancer treatment. Additionally, CCNF's role in other biological processes, such as gametogenesis and stem cell differentiation, underscores its multifaceted functions. As researchers continue to dissect the molecular mechanisms underlying CCNF's actions within the cell, these investigations promise to shed light on new avenues for understanding cell cycle regulation and the development of cancer therapies. Understanding the intricate roles of CCNF not only contributes to basic biological knowledge but also holds potential for clinical applications in oncology and regenerative medicine.
