Analytical Data
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Gene name
CDH2
- Application
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Alternative Names
CDH2; CDHN; NCAD; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD antigen CD325
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P19022
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Expression Region
160-724aa
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AA Sequence
DWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGI FIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVID MNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIV SQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPT YGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKD QPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFV LTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEG LHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVL DRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQE AETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNG DFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDC TDVDRIVGAGLGTGA
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Molecular Weight
99 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDH2, also known as N-cadherin, is a type of cadherin, a family of proteins that play crucial roles in cell adhesion, which is vital for the development and maintenance of tissue structure in multicellular organisms. CDH2 is primarily expressed in neural and muscle tissues, and its function is essential for facilitating cell-cell interactions during embryonic development, wound healing, and in the maintenance of tissue integrity. Research has shown that dysregulation of CDH2 expression is associated with various pathologies, including cancer metastasis, where its reduced expression correlates with the loss of cellular adhesion and increased cell migration. The study and production of recombinant CDH2 proteins have become increasingly important for elucidating its biological functions and for developing therapeutic strategies aimed at inhibiting cancer progression. Recombinant CDH2 proteins are utilized in various assays and experimental setups to better understand the molecular mechanisms underlying cell adhesion, signal transduction, and cellular communication. These studies also provide insights into potential biomarkers for disease progression and therapeutic targets. As such, recombinant CDH2 proteins represent an invaluable tool in biomedical research aimed at understanding not only fundamental biological processes but also disease mechanisms and potential interventions. The ongoing exploration of CDH2's role in health and disease highlights the protein's importance in both basic biological research and its translational applications in medicine.
