Cat: PA1000-7838

Recombinant Human HAUS7 Protein,His

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Analytical Data

  • Gene name

    HAUS7

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    HAUS7;UCHL5IP;UIP1;HAUS augmin-like complex subunit 7

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q99871

  • Expression Region

    1-368aa

  • AA Sequence

    MGGARLGARN MAGQDAGCGR GGDDYSEDEG DSSVSRAAVE VFGKLKDLNC PFLEGLYITE PKTIQELLCS PSEYRLEILE WMCTRVWPSL QDRFSSLKGV PTEVKIQEMT KLGHELMLCA PDDQELLKGC ACAQKQLHFM DQLLDTIRSL TIGCSSCSSL MEHFEDTREK NEALLGELFS SPHLQMLLNP ECDPWPLDMQ PLLNKQSDDW QWASASAKSE EEEKLAELAR QLQESAAKLH ALRTEYFAQH EQGAAAGAAD ISTLDQKLRL VTSDFHQLIL AFLQVYDDEL GECCQRPGPD LHPCGPIIQA THQNLTSYSQ LLQVVMAVAD TSAKAVETVK KQQGEQICWG GSSSVMSLAT KMNELMEK

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

HAUS7 is a key protein involved in the assembly and functionality of the microtubule organizing center, specifically within the context of the HUS1 complex, which plays a crucial role in cell division and the maintenance of genomic stability. Recent studies have highlighted its importance not only in the mitotic spindle assembly and positioning but also in response to cellular stress and DNA damage repair mechanisms. The HAUS complex, comprising several subunits including HAUS7, is essential for the proper organization of microtubules during mitosis, influencing processes such as chromosome segregation and spindle dynamics. Dysregulation of HAUS7 and associated proteins has been linked to various oncogenic pathways, suggesting its potential role as a therapeutic target in cancer treatment. Consequently, understanding the structure, function, and regulatory mechanisms of HAUS7 is crucial for elucidating its contribution to cellular processes and disease states. Research in this area aims to develop novel strategies for targeting HAUS7 in cancer therapy, as well as to advance our knowledge of microtubule dynamics and its implications in cellular function and stability.

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