Analytical Data
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基因名
DFNA5
- Application
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别名
2310037D07Rik; 4932441K13Rik; Deafness. autosomal dominant 5; Deafness. autosomal dominant 5 protein; DFNA5; DFNA5 gene; DFNA5_HUMAN; Dfna5h; EG14210; Fin15; ICERE 1; ICERE-1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60443
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表达区间
1-496aa
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氨基酸序列
MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGDVLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGKQGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLSPTVAVLGELKPRQQQDLVAFLQLVGCSLQGGCPGPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERLKSSVKAVILKDSKVFPLLLCITLNGLCALGREHS
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分子量
81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DFNA5, a gene associated with non-syndromic hearing loss, encodes a protein that plays a crucial role in the auditory system. Mutations or deletions in DFNA5 have been linked to autosomal dominant hearing impairment in various populations. Recent studies have highlighted the significance of DFNA5 in cochlear cell function and its involvement in apoptosis and cellular stress responses. The DFNA5 protein contains a unique structure that is essential for its function, and its disruption can lead to impaired auditory signaling pathways. Understanding the molecular mechanisms underlying DFNA5-related hearing loss is vital for developing targeted therapies and interventions. Research focusing on the recombinant expression of DFNA5 protein aims to elucidate its functional properties, interaction with other cellular proteins, and its role in hearing loss mechanisms. By generating recombinant DFNA5, scientists can explore potential therapies, such as gene therapy or small molecule drugs, that could restore hearing function or protect cochlear cells from degeneration. As a result, the study of DFNA5 recombinant protein continues to be a promising area in otology, with the potential to offer insights into treating genetic forms of hearing impairment.
