Analytical Data
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基因名
AIPL1
- Application
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别名
AIPL1；AIPL2；Aryl-hydrocarbon-interacting Protein-like 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZN9
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表达区间
1-384aa
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氨基酸序列
MDAALLLNVEGVKKTILHGGTGELPNFITGSRVIFHFRTMKCDEERTVIDDSRQVGQPMHIIIGNMFKLEVWEILLTSMRVHEVAEFWCDTIHTGVYPILSRSLRQMAQGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFVIELLQVDAPSDYQRETWNLSNHEKMKAVPVLHGEGNRLFKLGRYEEASSKYQEAIICLRNLQTKEKPWEVQWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNEAEAKADLQKVLELEPSMQKAVRRELRLLENRMAEKQEEERLRCRNMLSQGATQPPAEPPTEPPAQSSTEPPAEPPTAPSAELSAGPPAEPATEPPPSPGHSLQH
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分子量
70.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AIPL1 (A kinase interacting protein 1) is a protein that plays a crucial role in the phototransduction pathway within the retina, specifically in the functioning of photoreceptor cells. Mutations in the AIPL1 gene have been associated with various inherited retinal diseases, including Leber congenital amaurosis (LCA) and retinitis pigmentosa, leading to severe visual impairment or complete blindness. The study of AIPL1 recombinant protein aims to better understand its functional mechanisms, interaction with other proteins, and involvement in cellular processes. By producing AIPL1 in a recombinant form, researchers can investigate its structure-function relationships, identify the effects of specific mutations, and explore potential therapeutic interventions. This research is particularly important for developing gene therapies or pharmacological approaches that could restore or enhance the function of AIPL1 in affected patients. Furthermore, understanding the dynamics of AIPL1 can provide insights into broader pathways involved in retinal health and disease, making it a focal point in ocular genetics and regenerative medicine. Through the characterization of AIPL1 recombinant protein, scientists hope to pave the way for innovative treatments that could significantly improve the quality of life for individuals suffering from genetic vision disorders.
