Analytical Data
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Gene name
TRAF5
- Application
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Alternative Names
TRAF5；RNF84；TNF receptor-associated factor 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00463
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Expression Region
1-557aa
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AA Sequence
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
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Molecular Weight
80.4kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRAF5 (TNF Receptor-Associated Factor 5) is a crucial adaptor protein involved in various signaling pathways, particularly in the context of immune responses and inflammation. As a member of the TRAF family, TRAF5 plays a pivotal role in mediating the signaling of several receptors, including those of the tumor necrosis factor (TNF) superfamily. Research has shown that TRAF5 is implicated in processes such as T cell activation, B cell proliferation, and the production of pro-inflammatory cytokines, making it a significant factor in both innate and adaptive immunity. Dysregulation of TRAF5 has been linked to various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions. Consequently, the study of TRAF5 recombinant proteins has gained attention for their potential application in therapeutic strategies, aimed at modulating immune responses. By creating and characterizing TRAF5 recombinant proteins, researchers can better understand the molecular mechanisms governing its interactions and functions, paving the way for novel treatments that target TRAF5-related pathways. As we delve deeper into the structure and function of TRAF5, we uncover new insights into its role in health and disease, underscoring its relevance in immunological research and potential as a drug target.
