Analytical Data
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Gene name
TRADD
- Application
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Alternative Names
TRADD；Tumor necrosis factor receptor type 1-associated DEATH domain Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15628
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Expression Region
1-312aa
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AA Sequence
MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
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Molecular Weight
41.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRADD (TNFR1-associated death domain protein) is a crucial adaptor protein involved in the signaling pathways of Tumor Necrosis Factor receptor (TNFR) superfamily. It plays a significant role in mediating apoptosis and inflammatory responses by linking activated TNFRs to downstream signaling cascades, including the activation of caspases and the NF-κB pathway. Research on TRADD has gained momentum due to its dual function in promoting cell death and survival, making it a key player in various pathological conditions, including cancer and autoimmune diseases. TRADD interacts with several other proteins, such as FADD and TRAF2, enabling it to integrate multiple signaling pathways that regulate cellular responses to stress and damage. The study of TRADD's structure and function, particularly through recombinant protein techniques, has shed light on the molecular mechanisms underlying its action. By producing TRADD as a recombinant protein, researchers can investigate its interactions, post-translational modifications, and potential as a therapeutic target. Understanding TRADD's role in disease progression could lead to novel strategies for therapeutic interventions in conditions where TNF signaling is dysregulated. Thus, the exploration of TRADD recombination not only enriches our understanding of cell signaling but also holds promise for the development of targeted therapies in inflammatory and oncogenic disorders.
