Cat: PA1000-7944

Recombinant Human TINF2 Protein,His

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Analytical Data

  • Gene name

    TINF2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    TINF2;TIN2;TERF1-interacting nuclear factor 2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9BSI4

  • Expression Region

    2-451aa

  • AA Sequence

    ATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR YRHHERLCMG LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT KQDLRKILEA QETFYQQVKQ LSEAPVDLAS KLQELEQEYG EPFLAAMEKL LFEYLCQLEK ALPTPQAQQL QDVLSWMQPG VSITSSLAWR QYGVDMGWLL PECSVTDSVN LAEPMEQNPP QQQRLALHNP LPKAKPGTHL PQGPSSRTHP EPLAGRHFNL APLGRRRVQS QWASTRGGHK ERPTVMLFPF RNLGSPTQVI SKPESKEEHA IYTADLAMGT RAASTGKSKS PCQTLGGRAL KENPVDLPAT EQKENCLDCY MDPLRLSLLP PRARKPVCPP SLCSSVITIG DLVLDSDEEE NGQGEGKESL ENYQKTKFDT LIPTLCEYLP PSGHGAIPVS SCDCRDSSRP L

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

TINF2, or Telomerase Interacting Protein 2, is a crucial component of the telomere complex, playing a vital role in maintaining telomere stability and integrity. Telomeres, the protective caps at the ends of chromosomes, are essential for genomic stability, and their dysfunction is associated with aging, cancer, and various genetic disorders. Research into TINF2 has gained momentum due to its involvement in disorders like dyskeratosis congenita, which is characterized by premature aging and increased cancer risk linked to telomere shortening. Recent studies have highlighted the interaction of TINF2 with other telomeric proteins and telomerase, suggesting its significant role in telomere length regulation and cellular lifespan. Understanding the structural and functional properties of TINF2 through recombinant protein studies is pivotal for elucidating its mechanism of action within the telomere complex. This research aims not only to clarify the molecular underpinnings of telomere maintenance but also to explore potential therapeutic targets for age-related diseases and cancer, where telomere dysfunction is a critical factor. As such, the study of TINF2 recombinant proteins opens avenues for developing strategies to manipulate telomere biology, with promising implications for improving healthspan and providing novel insights into tumorigenesis.

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