Analytical Data
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Gene name
FZD7
- Application
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Alternative Names
FZD7; Frizzled-7; Fz-7; hFz7; FzE3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75084
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Expression Region
1-574aa
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AA Sequence
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
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Molecular Weight
88.77 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FZD7, or Frizzled Class Receptor 7, is a member of the Frizzled family of receptors that play critical roles in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. The dysregulation of FZD7 has been implicated in numerous diseases, especially cancer, where it can contribute to tumor progression and metastasis. Research surrounding FZD7 recombinant protein has gained traction due to its potential as a therapeutic target and a biomarker for cancer diagnosis and prognosis. By studying the structure and function of FZD7, scientists aim to understand its role in signaling mechanisms that influence cell proliferation, differentiation, and migration. Recombinant FZD7 proteins are being developed for various applications, including functional studies, the discovery of small molecule inhibitors, and the creation of antibodies for targeted therapies. Moreover, investigating the interactions between FZD7 and its ligands or downstream signaling components is crucial for elucidating the complexities of Wnt signaling. This research not only enhances our understanding of FZD7's biological significance but also opens avenues for innovative treatment strategies in FZD7-related disorders. Overall, the study of FZD7 recombinant proteins is a vital area of research with implications for both basic biology and clinical applications in oncology.
