Analytical Data
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基因名
FZD7
- Application
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别名
FZD7; Frizzled-7; Fz-7; hFz7; FzE3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75084
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表达区间
1-574aa
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氨基酸序列
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
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分子量
88.77 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FZD7, or Frizzled Class Receptor 7, is a member of the Frizzled family of receptors that play critical roles in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. The dysregulation of FZD7 has been implicated in numerous diseases, especially cancer, where it can contribute to tumor progression and metastasis. Research surrounding FZD7 recombinant protein has gained traction due to its potential as a therapeutic target and a biomarker for cancer diagnosis and prognosis. By studying the structure and function of FZD7, scientists aim to understand its role in signaling mechanisms that influence cell proliferation, differentiation, and migration. Recombinant FZD7 proteins are being developed for various applications, including functional studies, the discovery of small molecule inhibitors, and the creation of antibodies for targeted therapies. Moreover, investigating the interactions between FZD7 and its ligands or downstream signaling components is crucial for elucidating the complexities of Wnt signaling. This research not only enhances our understanding of FZD7's biological significance but also opens avenues for innovative treatment strategies in FZD7-related disorders. Overall, the study of FZD7 recombinant proteins is a vital area of research with implications for both basic biology and clinical applications in oncology.
