Analytical Data
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基因名
GJA3
- Application
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别名
GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6H8
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表达区间
1-435aa
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氨基酸序列
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKASRASSGRARPEDLAI
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分子量
47.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJA3, also known as Gap Junction Protein Alpha 3, is a member of the connexin family and plays a crucial role in intercellular communication by forming gap junctions that facilitate the direct transfer of ions and small molecules between adjacent cells. Research into GJA3 has gained prominence due to its significant involvement in various physiological processes, including embryonic development and cellular homeostasis, as well as its implications in several pathologies. Mutations in the GJA3 gene have been linked to congenital cataracts and other ocular disorders, highlighting its importance in eye health. Furthermore, aberrant expression of GJA3 has been associated with certain cancers and other diseases, suggesting a potential role in tumorigenesis and disease progression. Understanding the structure, function, and regulatory mechanisms of GJA3 through recombinant protein studies is essential for unraveling its biological significance and therapeutic potential. These studies not only aid in elucidating the molecular basis of related diseases but also offer insights into targeted treatment strategies, making GJA3 a focal point of interest in molecular biology, genetics, and clinical research. The development of recombinant GJA3 provides a powerful tool for investigating its functional properties, interactions, and clinical relevance, paving the way for new interventions and therapeutic avenues in precision medicine.
