Analytical Data
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Gene name
IL17RA/CD217
- Application
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Alternative Names
IL17RA；IL17R；Interleukin-17 receptor A
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Species
Human
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Source
HEK293
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Tag
C-hFc&His tag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96F46
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Expression Region
33-320aa
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AA Sequence
LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLW
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Molecular Weight
100 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Interleukin 17 receptor A (IL17RA) plays a pivotal role in mediating the effects of interleukin 17 (IL-17), a pro-inflammatory cytokine involved in various immune responses. The IL-17 family, particularly IL-17A, is crucial in promoting inflammation and is increasingly implicated in autoimmune disorders such as rheumatoid arthritis, psoriasis, and multiple sclerosis. Understanding the function of IL17RA is essential for developing therapeutic strategies aimed at modulating immune responses. Recombinant IL17RA protein has emerged as a vital tool for research, enabling scientists to investigate its structure, signaling pathways, and interactions with other proteins. By studying the recombinant form of IL17RA, researchers can better understand its role in pathogenic processes and explore its potential as a biomarker or therapeutic target. Moreover, research into IL17RA can facilitate the design of monoclonal antibodies that block IL-17 signaling, providing new options for the treatment of inflammatory diseases. The generation and characterization of recombinant IL17RA has opened avenues for elucidating its mechanisms of action and the broader implications of IL-17 signaling in health and disease.
