Analytical Data
-
Gene name
DOCK1
- Application
-
Alternative Names
DOCK180; Ced5; DOwnstream Of CrK; 180 kDa protein downstream of CRK
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q14185
-
Expression Region
Thr1200~Gln1435
-
Molecular Weight
32kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DOCK1 (Dedicator of Cytokinesis 1) is a member of the DOCK family of guanine nucleotide exchange factors (GEFs) crucial for regulating cell signaling and cytoskeletal remodeling. Research on DOCK1 has gained momentum due to its significant role in various physiological processes, including cell migration, adhesion, and morphology, which are critical for immune response and development. Furthermore, DOCK1 has been implicated in several pathological conditions, particularly in cancer, where its dysregulation can promote tumor progression and metastasis. The study of recombinant DOCK1 protein is essential for understanding its molecular mechanisms and interactions with other cellular proteins and signaling pathways. By producing and characterizing recombinant DOCK1, researchers aim to elucidate its function in cellular processes and its potential as a therapeutic target. Given its involvement in critical signaling pathways, the functional and structural analysis of DOCK1 may provide insights into targeted therapies for diseases associated with its aberrations. Overall, the investigation of DOCK1 recombinant protein represents a promising avenue for both basic biological research and the development of novel treatments for cancer and other diseases where DOCK1 plays a key role.
