Analytical Data
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Gene name
E2F6
- Application
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Alternative Names
E2F 6; E2F binding site modulating activity protein ; E2F transcription factor 6; E2F transcription factor 6 isoform 1; E2F-6; E2F6; E2F6_HUMAN; EMA; MGC111545; Transcription factor E2F6
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75461
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Expression Region
1-281aa
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Molecular Weight
58.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
E2F6 is a member of the E2F family of transcription factors that play a crucial role in regulating the cell cycle, DNA replication, and differentiation. Unlike other E2F proteins that primarily promote transcription of genes necessary for cell cycle progression, E2F6 functions as a transcriptional repressor. It is involved in the regulation of various developmental processes and is critical for maintaining cellular homeostasis. Abnormal expression of E2F6 has been associated with several types of cancer, highlighting its potential role as a tumor suppressor. Researchers have increasingly focused on the molecular mechanisms of E2F6, particularly its interactions with other proteins and its regulation of target genes. Studies utilizing recombinant E2F6 proteins seek to unravel its structure, function, and regulatory mechanisms, which may lead to potential therapeutic strategies for cancer and other diseases associated with cell cycle dysregulation. Understanding E2F6's role in transcriptional repression and its contributions to different biological pathways can provide valuable insights into the development of targeted therapies and novel approaches to cancer treatment.
