Analytical Data
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Gene name
NCS1
- Application
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Alternative Names
Frequenin homolog Frequenin-like protein Frequenin-like ubiquitous protein
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62166
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Expression Region
1-190aa
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Molecular Weight
48.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NCS1 (Neuronal Calcium Sensor 1) is a calcium-binding protein that plays a crucial role in various cellular processes, particularly in neuronal signaling and synaptic transmission. The study of NCS1's recombinant protein has garnered significant interest due to its implications in understanding neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where calcium dysregulation is a contributing factor. Research indicates that NCS1 can modulate neurotransmitter release and is involved in the regulation of ion channels and synaptic plasticity. The ability to express and purify NCS1 as a recombinant protein allows researchers to investigate its functional characteristics, binding properties, and structural conformation, facilitating the exploration of its role in calcium signaling pathways. Moreover, recombinant NCS1 can be utilized in high-throughput screening for potential therapeutic compounds that target calcium-mediated processes. In-depth characterization of this protein can lead to a better understanding of its pathophysiological roles and may provide insights into novel treatment strategies for related diseases. As such, NCS1 serves as an important model for studying the interplay between calcium signaling and neuronal function, making it a valuable subject in both basic and applied research in the field of neuroscience.
