Analytical Data
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Gene name
JMJD7
- Application
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Alternative Names
Jumonji domain-containing protein 7
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0C870
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Expression Region
1-316aa
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Molecular Weight
39.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JMJD7 is a member of the Jumonji C (JmjC) domain-containing protein family, characterized by its ability to catalyze the demethylation of lysine residues on histone proteins, thus influencing gene expression and chromatin dynamics. Understanding JMJD7's role is important, as it has been implicated in various biological processes, including cell differentiation, development, and the regulation of stress responses. Recent studies suggest that JMJD7 may be involved in the progression of several diseases, including cancer, by modulating histone methylation states. This positions it as a potential therapeutic target. Furthermore, the expression pattern of JMJD7 in different tissues and its interactions with other proteins indicate its diverse functional roles in cellular contexts. Research on recombinant JMJD7 protein aims to elucidate its structural properties and enzymatic functions, providing insights into its mechanism of action in epigenetic regulation. The development of recombinant JMJD7 also enables high-throughput screening for small-molecule inhibitors, which could lead to novel strategies for combating diseases associated with aberrant histone methylation. Overall, investigating JMJD7 holds significant promise for enhancing our understanding of epigenetic regulation and potential clinical applications in precision medicine.
