Analytical Data
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Gene name
KCNA1
- Application
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Alternative Names
Voltage-gated K(+) channel HuKI1
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q09470
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Expression Region
1-154aa
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Molecular Weight
22.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNA1, a member of the voltage-gated potassium channel family, plays a crucial role in regulating neuronal excitability and muscle contraction. It is encoded by the KCNA1 gene located on chromosome 12 and is known to influence action potential duration and repolarization in various excitable tissues. Mutations in the KCNA1 gene have been linked to several neurological disorders, most notably episodic ataxia type 1 (EA1), characterized by episodes of ataxia, myokymia, and muscle stiffness. The study of KCNA1 recombinant proteins has gained significant attention in the field of biomedical research, as these proteins can be expressed and purified in heterologous systems, allowing for detailed functional analyses. Understanding the structure-function relationship of KCNA1 through recombinant protein studies can provide insights into the mechanisms underlying its physiological role and the pathophysiology of related genetic disorders. Furthermore, the development of inhibitors or modulators targeting KCNA1 could lead to novel therapeutic strategies for conditions arising from its dysfunction. Overall, research into KCNA1 recombinant proteins is essential for advancing our understanding of ion channel biology and developing potential treatments for ion channelopathies.
