Analytical Data
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Gene name
LCK
- Application
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Alternative Names
Leukocyte C-terminal Src kinase ;LSKLymphocyte cell-specific protein-tyrosine kinaseProtein YT16Proto-oncogene LckT cell-specific protein-tyrosine kinasep56-LCK
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P06239
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Expression Region
1-539aa
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Molecular Weight
77.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LCK, or lymphocyte-specific protein tyrosine kinase, is a crucial component of T cell receptor signaling and plays a significant role in regulating immune responses. The research on LCK recombinant proteins has gained momentum due to their potential applications in immunotherapy and vaccine development. Understanding the structure and function of LCK is essential for elucidating the mechanisms behind T cell activation and signaling pathways. By generating recombinant LCK proteins, researchers aim to investigate the detailed biochemical properties and interactions of this kinase with other signaling molecules, as well as its role in various cellular processes. Additionally, recombinant LCK can be employed to develop novel therapeutic strategies for autoimmune diseases and cancers, where T cell dysregulation is a contributing factor. The production and characterization of LCK recombinant proteins provide valuable insights into their biological functions and can lead to innovative approaches in treating immune-related disorders. As the field of immunology continues to evolve, the study of LCK and its recombinant forms remains a promising area of research, with the potential to enhance our understanding of T cell biology and improve therapeutic interventions.
