Analytical Data
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Gene name
LDB3
- Application
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Alternative Names
Protein cypher Z-band alternatively spliced PDZ-motif protein
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75112
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Expression Region
1-283aa
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LDB3 (LIM domain binding 3) is a crucial component implicated in the regulation of gene expression and cellular signaling pathways, particularly in cardiac and skeletal muscle development. Recent studies have shown that mutations and dysregulation of LDB3 are associated with various cardiac abnormalities and muscle disorders, emphasizing its role in maintaining muscle integrity and function. The research into LDB3 recombinant proteins aims to elucidate its molecular mechanisms and interactions within muscle cells. By expressing LDB3 in a recombinant system, scientists can produce significant quantities of the protein for detailed biochemical and biophysical analyses. This research is vital for understanding how LDB3 contributes to muscle cell differentiation, organization of the cytoskeleton, and response to mechanical stress. Furthermore, delineating the functional properties of LDB3 could pave the way for therapeutic strategies targeting muscle pathologies linked to its dysfunction. Insights gained from LDB3 studies may ultimately contribute to the development of biomolecular therapies and intervention strategies for patients suffering from myopathies and cardiomyopathies, highlighting the protein's significance in both basic research and clinical applications.
