Analytical Data
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基因名
NR1I2
- Application
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别名
Orphan nuclear receptor PAR1 Orphan nuclear receptor PXR Pregnane X receptor Steroid and xenobiotic receptor
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75469
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表达区间
1-434aa
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分子量
69.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NR1I2, also known as Pregnane X Receptor (PXR), is a nuclear receptor that plays a crucial role in the regulation of genes involved in drug metabolism and excretion. Research into NR1I2 has gained significant attention due to its involvement in the body's response to xenobiotics, including pharmaceuticals and environmental toxins. PXR functions as a molecular sensor that activates the transcription of target genes by binding to various ligands, thereby increasing the expression of cytochrome P450 enzymes, transporters, and other proteins necessary for drug clearance. Understanding the structure and function of NR1I2 is critical for elucidating mechanisms of drug-drug interactions, variability in drug metabolism among individuals, and the development of therapeutics that can modulate this receptor for improved drug efficacy and safety. Recombinant NR1I2 proteins are essential for these studies, as they provide a platform for in vitro assays, structural biology investigations, and high-throughput screening of potential ligands. Advances in the production and characterization of NR1I2 recombinant proteins have the potential to facilitate drug discovery and personalized medicine by allowing researchers to better predict how different individuals might respond to medications based on their genetic makeup and the presence of various environmental factors. Consequently, ongoing research into NR1I2 not only enhances our understanding of pharmacology but also highlights the significance of nuclear receptors in human health and disease.
