Analytical Data
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Gene name
Nr5a2
- Application
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Alternative Names
Liver receptor homolog 1 (LRH-1) (Lrh1)
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P45448
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Expression Region
1-560aa
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Molecular Weight
71.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nr5a2, also known as Liver Receptor Homolog-1 (LRH-1), is a nuclear receptor that plays a crucial role in various biological processes, including endocrine regulation, liver development, and metabolism. It is involved in the expression of genes related to lipid metabolism, steroidogenesis, and glucose homeostasis, making it a significant target in understanding metabolic diseases and liver disorders. Research has shown that Nr5a2 is essential for the maintenance of pancreatic beta-cell function and plays a protective role in the progression of diabetes. Recent studies have focused on generating recombinant Nr5a2 protein to elucidate its structure-function relationship and regulatory mechanisms. The production of Nr5a2 as a recombinant protein allows for in-depth biochemical assays and the exploration of its interactions with other proteins and ligands. This research holds promise for developing therapeutic strategies for metabolic disorders and advancing our understanding of nuclear receptor signaling pathways. As we continue to investigate the implications of Nr5a2 in health and disease, recombinant protein studies are instrumental in revealing potential drug targets and treatment avenues for related conditions.
