Analytical Data
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Gene name
CYP3A43
- Application
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HB55
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Expression Region
1-393aa
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Molecular Weight
52.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP3A43 is a member of the cytochrome P450 family of enzymes, primarily involved in the metabolism of a wide range of endogenous and exogenous compounds, including drugs and steroids. The interest in CYP3A43 has grown due to its potential role in pharmacogenetics, as variations in its gene can influence drug metabolism and response, potentially leading to adverse drug reactions or therapeutic failures. Unlike its more extensively studied relatives CYP3A4 and CYP3A5, CYP3A43 exhibits unique substrate specificity and expression patterns, which may critically impact individual drug clearance. Recent studies suggest that CYP3A43 may be involved in the metabolic activation of certain prodrugs, highlighting its importance in drug development and personalized medicine. Additionally, investigations into its structure and function provide insights into the complex regulation of the cytochrome P450 enzyme system. Understanding the functional characteristics and polymorphic variants of CYP3A43 could lead to improved dosing strategies and safer therapeutic options for patients, making it a significant target for ongoing research.
