Analytical Data
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Gene name
NCOR2
- Application
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Alternative Names
NCOR2；CTG26；Nuclear receptor corepressor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y618
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Expression Region
1-312aa
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AA Sequence
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKK
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Molecular Weight
42.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NCOR2, or Nuclear Receptor Co-Repressor 2, is a crucial regulatory protein involved in the transcriptional repression of various nuclear receptors, which play significant roles in numerous biological processes, including metabolism, development, and cell differentiation. Its function is primarily to interact with nuclear receptors and facilitate the recruitment of histone deacetylases and other corepressors, leading to chromatin remodeling and repression of gene expression. Research on NCOR2 has gained momentum due to its implication in various diseases, particularly cancers and metabolic disorders. Dysregulation of NCOR2 has been associated with the development and progression of tumors, making it a potential therapeutic target. Furthermore, NCOR2's interactions with different signaling pathways suggest that it may serve as a critical node in the network of cellular responses to external stimuli. The production of recombinant NCOR2 protein enables the detailed study of its structure-function relationships, interactions with nuclear receptors, and its role in gene regulation. Such recombinant proteins are invaluable for dissecting the molecular mechanisms of NCOR2 action, offering insights into its potential as a drug target and therapeutic agent in diseases linked to its dysfunction. Understanding the biochemical properties and interactions of NCOR2 through recombinant protein studies may foster the development of innovative strategies for disease intervention and highlight its relevance in the context of nuclear receptor signaling pathways.
