Analytical Data
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基因名
KNCN
- Application
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别名
KNCN; Kinocilin
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A6PVL3
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表达区间
1-136aa
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氨基酸序列
MLRQSLSGCPCPALPSCLLPLCQCPPGLGDPDRRQARPCRPQSGWEQCLEWGLLHSPGQASPKWIPLVWAGTWSKVSPDAPTGFPCFRLLPWPFFLDCSSALLPVQSTDLFLWNLGSRALTMTRMPQSLALTRLQK
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分子量
41.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KNCN (K+ channel-interacting protein C-novel) is a member of the K+ channel-interacting protein family, which plays a crucial role in modulating the activity of voltage-gated K+ channels. In recent years, KNCN has garnered attention for its potential involvement in various physiological and pathological processes, including neuronal excitability, cardiac function, and tumor biology. Research indicates that KNCN may interact with specific K+ channels, influencing their gating and localization, which could have significant implications for understanding diseases such as arrhythmias, epilepsy, and cancer. By exploring the structural and functional characteristics of KNCN through recombinant protein studies, scientists aim to elucidate its role in these processes. The generation of recombinant KNCN protein allows for detailed investigation of its interactions with K+ channels and other cellular partners, paving the way for potential therapeutic applications. Furthermore, understanding KNCN's structure-function relationship may provide insights into its regulatory mechanisms and open new avenues for drug discovery. This research is essential not only for basic scientific knowledge but also for developing targeted treatments for diseases linked to dysregulated K+ channel activity.
