Analytical Data
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Gene name
KNS2
- Application
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Alternative Names
CDCBM3; HK2; KIF2; KIF2A; KIF2A_HUMAN; Kinesin 2; Kinesin heavy chain 2; Kinesin heavy chain member 2; Kinesin heavy chain member 2A ; Kinesin like protein KIF2A; Kinesin-2; Kinesin-like protein KIF2A; KNS2; M Kinesin
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00139
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Expression Region
1-706aa
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AA Sequence
MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL
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Molecular Weight
79.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KNS2, also known as Kynurenine 2, is a protein involved in the metabolism of tryptophan, an essential amino acid that serves as a precursor for several bioactive compounds, including neurotransmitters and kynurenines. The interest in KNS2 has surged due to its potential role in modulating various physiological and pathological processes, including immune responses, neurodegenerative diseases, and psychiatric disorders. Recent studies have indicated that alterations in kynurenine metabolism may influence the progression of conditions like depression, schizophrenia, and Alzheimer's disease. As a result, researchers are focusing on characterizing KNS2 and its functional attributes, particularly its enzymatic activities and regulatory mechanisms. The production of recombinant KNS2 proteins has become a key aspect of this research, enabling detailed investigations into the structure-function relationships of the protein. By utilizing recombinant protein technology, scientists can generate purified KNS2, facilitating studies on its interaction with other biomolecules and its role in metabolic pathways. Furthermore, understanding the functional dynamics of KNS2 could open new avenues for therapeutic interventions aimed at modulating kynurenine pathways in disease contexts. Overall, the study of KNS2 and its recombinant forms represents a growing field with significant implications for understanding metabolic disorders and developing targeted therapies.
