Analytical Data
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基因名
LMX1A
- Application
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别名
HGNC:6653; LIM homeobox protein 1.1; LIM homeobox transcription factor 1 alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX 1; LMX 1.1; LMX 1A; LMX-1.1; LMX1; LMX1.1; LMX1A; LMX1A_HUMAN; MGC87616
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TE12
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表达区间
1-382aa
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氨基酸序列
MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
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分子量
42.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LMX1A (LIM homeobox transcription factor 1 alpha) is a crucial transcription factor that plays a significant role in the development of various tissues, particularly in the specification of neuronal and musculoskeletal lineages. Research has shown that LMX1A is involved in the formation of dopaminergic neurons, which are vital for the regulation of movement and are notably affected in neurodegenerative disorders such as Parkinson's disease. Due to its pivotal role in these developmental processes, LMX1A has garnered attention in regenerative medicine and stem cell research, where scientists aim to manipulate its expression to promote the differentiation of stem cells into functional neurons for therapeutic purposes. Furthermore, alterations in LMX1A expression have been implicated in congenital anomalies, highlighting its importance in embryonic development. The recombination and expression of LMX1A as a recombinant protein provide a valuable tool for studying its functional properties, elucidating its molecular mechanisms, and exploring its potential applications in cell therapy and tissue engineering. By generating LMX1A recombinant protein, researchers can better investigate its interactions with other proteins, its regulatory pathways, and its overall impact on cellular physiology. This research avenue not only aids in understanding the fundamental biological processes governed by LMX1A but also opens new avenues for targeted therapies that leverage its functions in neural development and regeneration.
