Analytical Data
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基因名
SEPT5
- Application
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别名
SEPTIN5;PNUTL1;SEPT5;Septin-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99719
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表达区间
1-369aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMSTGLRYKSKLATPEDKQDIDKQYVGF ATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLS AEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITD YVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKA LHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDE DEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAH CDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMES PIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEPT5, a member of the septin family of GTP-binding proteins, plays a crucial role in various cellular processes, including cytokinesis, cell division, and cytoskeletal organization. The study of SEPT5 has gained significant attention due to its involvement in neurobiology, particularly in synaptic function and neuronal development. Abnormalities in SEPT5 expression and function have been linked to several diseases, including neurodegenerative disorders and cancers, highlighting its potential as a therapeutic target. Researchers have focused on the structural properties and functional dynamics of SEPT5, utilizing advanced techniques such as cryo-electron microscopy and x-ray crystallography to elucidate its interactions with other proteins and cellular components. Furthermore, understanding the regulation of SEPT5 activity in response to cellular signals is essential for unveiling its role in pathophysiological conditions. This research not only contributes to the fundamental knowledge of septin biology but also opens avenues for the development of novel strategies for disease intervention, showcasing the importance of SEPT5 in both health and disease.
