Analytical Data
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基因名
SEPT6
- Application
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别名
SEPTIN6;KIAA0128;SEP2;SEPT6;Septin-6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14141
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表达区间
1-434aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAATDIARQVGEGCRTVPLAGHVGFDS LPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQP GVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFE AYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKV NIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEING TMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREM LIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAK RNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQD EKKKLEDKKKSLDDEVNAFKQRKTAAELPQSQGSQAGGSQTLKRDKEKKN NPWLCTE
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEPT6, a member of the septin family of proteins, plays a crucial role in various cellular processes, including cell division, cytoskeletal organization, and membrane dynamics. Septins are characterized by their ability to form hetero-oligomeric complexes that contribute to the formation of filamentous structures, acting as scaffolding components in the cytoplasm. Research into SEPT6 has gained momentum due to its involvement in significant pathological conditions, including cancer and neurodegenerative disorders. Studies have shown that SEPT6 interacts with a variety of cellular partners, influencing cell signaling pathways and contributing to the regulation of essential cellular functions. Moreover, the dysregulation of SEPT6 has been linked to tumorigenesis, making it a potential biomarker for cancer progression and a target for therapeutic interventions. Recent advances in structural biology techniques, such as cryo-electron microscopy and X-ray crystallography, have provided insights into the molecular architecture of SEPT6 and its complexes, paving the way for the development of novel drugs that can modulate its activity. Overall, the ongoing exploration of SEPT6 and its functional implications in health and disease underscores its significance in cellular biology and its potential as a therapeutic target.
