Analytical Data
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Gene name
SNTA1
- Application
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Alternative Names
SNTA1;SNT1;Alpha-1-syntrophin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13424
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Expression Region
1-505aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMASGRRAPRTGLLELRAGAGSGAGGER WQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQL PEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTE ALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFK NSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCT PNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKD ELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSL PETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVD THLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHI DKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQL DLHSCPKTIVFIIHSFLSAKVTRLGLLA
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Molecular Weight
56 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNTA1, or Syntrophin Alpha 1, is a member of the syntrophin family of proteins, which are crucial for the proper functioning of dystrophin-associated protein complexes in muscle and neuronal tissues. These complexes play a vital role in maintaining cellular membrane integrity, facilitating signal transduction, and anchoring ion channels and receptors. Research surrounding SNTA1 has gained significance due to its involvement in various pathophysiological conditions, such as muscular dystrophies and neurodegenerative diseases. Studies have suggested that dysregulation or mutations in SNTA1 can lead to impaired muscle function and contribute to the progression of disorders like Duchenne muscular dystrophy. Moreover, SNTA1 is implicated in cellular processes beyond muscle, including its interactions with several signaling pathways and potential roles in neurotransmitter release. The exploration of SNTA1 as a therapeutic target has led to an increased interest in developing recombinant SNTA1 proteins, which can be utilized for functional assays, antibody production, and further studies on its cellular mechanisms. Understanding the structure and function of SNTA1 at a molecular level will provide insights into its physiological roles and potential implications in disease, opening avenues for novel therapeutic strategies aimed at targeting syntrophin-related pathologies.
