Analytical Data
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Gene name
TESK2
- Application
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Alternative Names
TESK2；Dual specificity testis-specific Protein kinase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96S53
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Expression Region
1-571aa
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AA Sequence
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAF SRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLK EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPW TVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGL AEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEII ARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDK IPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVN PFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGTMPLADWQEPLAPP IRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFR ASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPAG STPATFSTSGIGLQTQGKQDG
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Molecular Weight
92 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TESK2 (Testis-Specific Kinase 2) is a member of the Ste20-like kinase family, primarily expressed in testicular tissues and certain cancer cells. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival, making it a significant focus of research in both reproductive biology and cancer therapy. The kinase is involved in signaling pathways that modulate cytoskeletal dynamics and cellular responses to external stressors. Abnormal expression or activity of TESK2 has been associated with various malignancies, suggesting its potential as a biomarker for cancer diagnosis and a target for therapeutic interventions. Recent studies have explored the mechanisms by which TESK2 regulates cell functions and its implications in tumorigenesis, highlighting its importance in understanding the molecular underpinnings of cancer. Additionally, the development of recombinant TESK2 proteins allows for detailed investigations into its enzymatic activity, interaction with other molecules, and the potential for designing inhibitors that can disrupt its function. The ongoing research on TESK2 not only enhances our understanding of male reproductive health but also opens new avenues for targeted cancer therapies, emphasizing its significance in both developmental and pathological contexts.
