Analytical Data
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基因名
TPM1
- Application
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别名
TPM1；C15orf13；Tropomyosin alpha-1 chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09493
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表达区间
1-284aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMDAIKKKMQMLKLDKENALDRAEQAEADKK AAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATD AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI ESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE ERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSD KLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALND MTSM
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPM1 (tropomyosin 1) is a key actin-binding protein that plays a vital role in the regulation of muscle contraction and cellular processes in various tissues. It is a member of the tropomyosin family, which consists of distinct isoforms that are expressed in non-muscle and muscle cells. Research into TPM1 has gained significance due to its involvement in cardiac and skeletal muscle function, as well as its contribution to the structural stability of the cytoskeleton. Mutations in the TPM1 gene have been linked to various myopathies and inherited cardiomyopathies, highlighting its importance in muscle pathology. The recombinant protein of TPM1 is often produced for research purposes to study its biochemical properties and interactions with other proteins, such as actin and myosin. Understanding the mechanisms of TPM1 function could provide insights into muscle disorders and lead to potential therapeutic strategies. Moreover, studying the structure and dynamics of TPM1 through recombinant protein techniques allows for a deeper exploration of tropomyosin's role in cellular signaling and mechanical properties. As a result, ongoing research aims not only to elucidate the molecular underpinnings of muscle function but also to develop targeted interventions for muscle-related diseases that arise from TPM1 dysfunction.
