Analytical Data
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Gene name
BTN3A1
- Application
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Alternative Names
BTN3A1；BTF5；Butyrophilin subfamily 3 member A1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00481
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Expression Region
31-254aa
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AA Sequence
FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP FFRSAQRWIA ALAG
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Molecular Weight
53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BTN3A1, a member of the butyrophilin family, plays a critical role in the immune response, particularly in the context of presenting antigens to T cells. It is involved in the recognition and modulation of various immune pathways, influencing both innate and adaptive immunity. Recent studies have highlighted its importance in the activation of γδ T cells, which are pivotal in the early response to infections and tumors. BTN3A1 interacts with phosphoantigens, leading to the activation of these unconventional T cells, thus making it a potential target for immunotherapy. Researchers have been exploring recombinant BTN3A1 proteins for their utility in studying T cell activation mechanisms and developing novel therapeutic strategies. The recombinant versions of BTN3A1 can facilitate precise investigations into its structural and functional properties, aiding in the understanding of its role in immune regulation. Additionally, these studies might provide insights into manipulating γδ T cell responses in cancer and infectious diseases, highlighting BTN3A1 as a promising candidate for the development of targeted immunotherapies.
