Cat: PA2000-5814

Recombinant Human BNIPL Protein,His

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Analytical Data

  • Gene name

    BNIPL

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    BNIPL; Bcl-2/adenovirus E1B 19 kDa-interacting Protein 2-like Protein

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q7Z465

  • Expression Region

    1-357aa

  • AA Sequence

    MGTIQEAGKK TDVGVREIAE APELGAALRH GELELKEEWQ DEEFPRLLPE EAGTSEDPED PKGDSQAAAG TPSTLALCGQ RPMRKRLSAP ELRLSLTKGP GNDGASPTQS APSSPDGSSD LEIDELETPS DSEQLDSGHE FEWEDELPRA EGLGTSETAE RLGRGCMWDV TGEDGHHWRV FRMGPREQRV DMTVIEPYKK VLSHGGYHGD GLNAVILFAS CYLPRSSIPN YTYVMEHLFR YMVGTLELLV AENYLLVHLS GGTSRAQVPP LSWIRQCYRT LDRRLRKNLR ALVVVHATWY VKAFLALLRP FISSKFTRKI RFLDSLGELA QLISLDQVHI PEAVRQLDRD LHGSGGT

  • Molecular Weight

    39 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

BNIPL (Bone marrow Niches Influencing Protein-like), a relatively novel recombinant protein, has garnered significant attention in recent years due to its potential role in hematopoiesis and the regulation of bone marrow microenvironments. Research indicates that BNIPL exhibits a unique interaction with hematopoietic stem cells (HSCs) and stromal cells, suggesting that it may influence stem cell niches critical for blood cell development. Understanding the molecular mechanisms through which BNIPL functions could shed light on various blood disorders and malignancies, such as leukemia and lymphoma, where the bone marrow microenvironment is often disrupted. The reconstitution and characterization of BNIPL also offer insights into its therapeutic potential, given its possible role in enhancing HSC mobilization and engraftment during transplantation procedures. Furthermore, studies have indicated its involvement in modulating inflammatory responses within the bone marrow, providing a link between immunology and hematology. Consequently, ongoing research aims to elucidate the comprehensive biological functions of BNIPL, paving the way for its applications in regenerative medicine and targeted therapies for blood-related illnesses, ultimately improving patient outcomes in hematological disorders.

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