Analytical Data
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Gene name
PLD4
- Application
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Alternative Names
PLD4；C14orf175；5'-3' exonuclease PLD4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BZ4
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Expression Region
52-506aa
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AA Sequence
WQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEAEARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDIGVNDSSSQLGEALLQKLQQLLGRNISLAVATSSPTLARTSTDLQVLAARGAHVRQVPMGRLTRGVLHSKFWVVDGRHIYMGSANMDWRSLTQVKELGAVIYNCSHLAQDLEKTFQTYWVLGVPKAVLPKTWPQNFSSHFNRFQPFHGLFDGVPTTAYFSASPPALCPQGRTRDLEALLAVMGSAQEFIYASVMEYFPTTRFSHPPRYWPVLDNALRAAAFGKGVRVRLLVGCGLNTDPTMFPYLRSLQALSNPAANVSVDVKVFIVPVGNHSNIPFSRVNHSKFMVTEKAAYIGTSNWSEDYFSSTAGVGLVVTQSPGAQPAGATVQEQLRQLFERDWSSRYAVGLDGQAPGQDCVWQG
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Molecular Weight
66.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLD4 (phospholipase D4) is a member of the phospholipase D family, which plays critical roles in various cellular processes, including membrane trafficking, signal transduction, and inflammation. Emerging studies have linked PLD4 to processes such as lipid metabolism and immune response, making it a potential target for therapeutic intervention in immune-related disorders and cancer. Research indicates that PLD4 is involved in the generation of phosphatidic acid from phosphatidylcholine, a key signaling molecule that regulates cell growth and differentiation. Furthermore, mutations or alterations in PLD4 expression have been associated with several diseases, including autoimmune conditions and certain types of cancer, highlighting its significance in health and disease. Understanding the structure, enzymatic activity, and regulatory mechanisms of PLD4 is crucial for elucidating its biological functions and potential as a drug target. Recent advancements in recombinant protein technology have enabled the production of functional PLD4 proteins, facilitating in-depth studies of its biochemical properties and interaction partners. Investigating PLD4's role in cellular pathways is expected to provide insights into its contributions to both normal physiology and pathological conditions, opening avenues for novel therapeutic strategies aimed at modulating its activity in disease contexts. As such, PLD4 represents a compelling focus for ongoing and future research in the field of molecular biology and pharmacology.
