Analytical Data
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Gene name
GRIA2
- Application
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Alternative Names
GRIA2；GluA2；GLUR2；Glutamate receptor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P42262
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Expression Region
25-543aa
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AA Sequence
NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA
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Molecular Weight
63.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GRIA2, also known as Glutamate Receptor Ionotropic, Amplified 2, is a pivotal subunit of the AMPA receptor, which plays a crucial role in fast synaptic transmission in the central nervous system. As a key component of excitatory neurotransmission, GRIA2 is implicated in various physiological processes, including learning and memory. Dysregulation of GRIA2 has been associated with several neurological disorders, such as epilepsy, schizophrenia, and mood disorders. Research into GRIA2 recombinant proteins has garnered significant attention due to their potential for therapeutic applications and their utility in studying receptor functions and interactions. By producing GRIA2 recombinant proteins, scientists can investigate the receptor's structure, ligand-binding properties, and interaction with auxiliary proteins, offering insights into its physiological roles and pathological implications. Additionally, these recombinant proteins serve as valuable tools for screening pharmacological agents that may modulate GRIA2 activity, paving the way for novel strategies in treating conditions linked to excitatory neurotransmission dysfunction. The ongoing exploration of GRIA2 recombinant proteins holds promise for advancing our understanding of synaptic mechanisms and developing targeted interventions for related neurological disorders.
