Analytical Data
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Gene name
SSBP3
- Application
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Alternative Names
SSBP3; SSDP; SSDP1Single-stranded DNA-binding Protein 3; Sequence-specific single-stranded-DNA-binding Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BWW4
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Expression Region
1-388 aa
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AA Sequence
MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI TLGEPPGFLH SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP VLGNIPPNDG MPGGPIPPGF FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL LPNSMDPTRQ QGHPNMGGSM QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG PGAGRPWPNP NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN ISGISNPPGT PRDDGELGGN FLHSFQNDNY SPSMTMSV
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Molecular Weight
40.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SSBP3 (Single-stranded DNA Binding Protein 3) is a crucial component in the regulation of DNA metabolism, playing significant roles in processes such as DNA replication, repair, and recombination. The protein is known to interact with single-stranded DNA, stabilizing it and preventing secondary structure formation which could impede essential cellular functions. Recent studies have highlighted its involvement in mitochondrial DNA maintenance and its potential implications in various disorders, such as cancers and mitochondrial dysfunction syndromes. As research progresses, the functional characterization of SSBP3 has become paramount, particularly the understanding of its structural properties, binding affinities, and interaction mechanisms with nucleic acids. This necessitates the production of recombinant SSBP3 proteins, which can be utilized in biochemical assays to elucidate these properties further. The generation of these proteins often involves the use of heterologous expression systems, allowing researchers to obtain large quantities of purified SSBP3 for in-depth studies. By exploring the functional and structural nuances of SSBP3, scientists aim to unravel its contributions to genomic stability, cellular health, and the molecular underpinnings of diseases associated with its dysfunction. The growing body of research surrounding SSBP3 not only fosters a deeper understanding of DNA binding proteins but also indicates potential therapeutic targets for interventions in genomic instability-related pathologies.
